Understanding Methotrexate: Risks and Side Effects


Methotrexate is a prescription medication used to treat cancer, rheumatoid arthritis, and psoriasis. It can cause non threatening as well as life-threatening side effects. Contact your doctor when experiencing medication side effects.

Methotrexate has several brand names: Rheumatrex, Trexall, Xatmep, Jylamvo, Otrexup, and RediTrex.

Methotrexate Side Effects

  • Mouth sores
  • Nausea
  • Fever
  • Dizziness
  • Stomach pain
  • Tiredness
  • Chills
  • Infection
  • Fever
  • Cough
  • Sore throat
  • Wounds that don’t heal
  • Bleeding
  • Liver, kidney or bone marrow damage
  • Allergic reactions
  • Blood clots
  • Shortness of breath
  • Chest pain
  • Dry cough, shortness of breath or trouble breathing
  • Low red blood cell count
  • Weakness, fatigue, dizziness, headache
  • Seizures
  • Unusual bruising or bleeding
  • Diarrhea
  • Hair Loss
  • Pain, redness or swelling with mouth or throat sores
  • Vomiting


Leave a comment